3D disease model services for your therapeutic program
Partner with Inventia scientists to develop, run, and transfer RASTRUM-based 3D disease models aligned to your biology, therapeutic area, and context of use.
Whether you need a pancreatic cancer model for a defined context of use, a tumor-stroma model to evaluate therapeutic response, or a custom 3D model for a specific disease biology, Discovery Services helps you move from research question to interpretable 3D data.
Our scientific team can support model development, treatment-response studies, assay readouts, reporting, and transfer into your lab when appropriate.
Disease models and therapeutic areas we support
Whether you need a pancreatic cancer model for a defined context of use, a tumor-immune model to evaluate response, or a custom 3D model for a specific disease biology, Inventia Discovery Services can help design, develop, run, and transfer models aligned to your program goals.
3D oncology and tumor microenvironment models for therapeutic response, mechanism, and context-of-use studies.
Inventia Discovery Services supports oncology teams developing 3D models that incorporate tumor biology, stromal interaction, matrix effects, and treatment response in more biologically relevant model systems.
Disease areas include:
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Common questions we help address:
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Example applications:
Tumor-stroma co-culture, patient-derived tumor models, tumor mechanobiology, therapeutic response, resistance biology, combination studies, ADC or targeted therapy evaluation where appropriate.
3D tumor-immune models for studying immune cell behavior, activation, infiltration, and therapeutic response.
Discovery Services can support development of tumor-immune model systems when immune cell interaction, cytokine response, immune-mediated killing, or infiltration is central to the research question.
Common questions we help address:
- Can immune cells access or interact with the tumor model?
- Does the model support immune-mediated response readouts?
- Can cytokine, imaging, or functional readouts be incorporated?
- How does the tumor microenvironment influence immune response?
Example applications:
Tumor-immune co-culture, immune cell infiltration, cytokine response, immune-mediated tumor killing, checkpoint or immune-modulating therapy studies, IO assay feasibility.
Discuss an immuno-oncology model
3D stromal biology models for fibroblast activation, and disease-associated signaling.
Discovery Services can support teams studying fibroblast behavior, stromal signaling,CAF biology, and fibrosis-related therapeutic questions.
Common questions we help address:
- Can fibroblast activation be modeled reproducibly in 3D?
- Does a treatment alter stromal cell activity?
- Should fibroblasts, CAFs, or stromal components be incorporated into a more complex disease model?
- Can the model support functional or molecular readouts of activation?
Example applications:
Fibroblast activation, CAF biology, TGF-β response, stromal signaling, tumor-stroma model development.
Discuss a fibroblast or stromal model
Custom 3D models for neurodegenerative disease research and therapeutic discovery.
Discovery Services can support development of 3D models for neurodegenerative disease programs where teams need a fit-for-purpose model to better represent disease biology, evaluate therapeutic response, or generate feasibility data.
Common questions we help address:
- Can a 3D model be developed around our neurodegenerative disease biology?
- What model format and readouts are appropriate for our research question?
- Can Inventia help generate feasibility data before internal adoption?
- Can the model support downstream analysis or therapeutic testing?
Example applications:
Custom neurodegenerative disease model development, therapeutic testing, model feasibility, assay development, downstream readout integration.
Discuss a neurodegenerative disease model
Custom 3D disease model development for programs that do not fit a predefined workflow.
Do not see your disease area listed? Discovery Services can help assess whether RASTRUM is a fit for your disease biology, cell source, co-culture system, model architecture, readout needs, and context of use.
Best for teams that need:
- A model for a specific disease biology
- A custom context-of-use workflow
- Feasibility data before internal development
- Support adapting an exploratory 3D model into a repeatable study
- Help deciding whether Discovery Services, Discovery Mode, or a Validated Solution is the right path
Example applications:
Custom disease models, novel co-culture systems, patient-derived model development, assay feasibility, readout development, workflow transfer.
Ask about a custom disease model
How Discovery Services supports your study
Once the disease model and therapeutic question are defined, Inventia scientists help build the study around the data you need.
Build or adapt the disease model
Develop a RASTRUM-based 3D model around your disease biology, cell source, co-culture needs, and context of use.
Generate therapeutic response data
Run treatment-response, screening, or functional studies using agreed model conditions and readouts.
Connect the model to useful readouts
Support imaging, viability, cytokine, molecular, or other downstream assays aligned to the study question.
Report and transfer
Provide data, interpretation, protocols, recommendations, and support for internal adoption where appropriate.
A collaborative path from disease question to usable 3D data
Define the disease model and study goal
We align on the disease biology, therapeutic question, context of use, cell system, and success criteria.
Build and optimize the model
Inventia scientists develop or adapt the 3D model conditions needed to support the study.
Run the study and generate data
We execute the agreed treatment-response, functional, or mechanistic study using fit-for-purpose readouts.
Report, recommend, and transfer
You receive data, interpretation, recommendations, and, where appropriate, protocols and support for internal adoption.
What you receive
Deliverables are tailored to your project scope and designed to help your team interpret the data, reproduce the model, and decide what to do next.
Study design
Experimental design aligned to your disease model, therapeutic question, and context of use.
3D model recommendations
Recommended model conditions, matrix and architecture guidance, culture parameters, and QC considerations.
Data and interpretation
Treatment-response, functional, imaging, molecular, or other agreed data with scientific interpretation.
Protocols and transfer support
Protocols, SOP-style guidance, QC criteria, and recommendations to support continued use or internal transfer where appropriate
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Not sure which path fits your program?
Discovery Services is one route within the broader RASTRUM ecosystem.
If your team wants to build and iterate independently, Discovery Mode may be the right starting point. If a predefined workflow already matches your context of use, a Validated Solution may be the fastest path. If you need Inventia scientists to help develop, run, customize, or transfer a disease model, Discovery Services can help.
Explore Discovery Mode
For teams developing their own RASTRUM workflows with maximum flexibility.
Browse Validated Solutions
For teams starting from a predefined workflow with supporting data for a specific context of use.
Meet the RASTRUM™ Platform
Explore this powerful technology for generating reproducible, scalable 3D cell models.
We are thrilled to partner with Inventia Life Science to develop more physiologically relevant models for neurodegenerative diseases. These models will be key for our future drug discovery initiatives.
Executive Director, Top 20 Pharma
Ready to discuss a 3D disease model for your program?
Tell us the disease biology, therapeutic question, cell system, or context of use you need to model. Inventia scientists can help identify whether Discovery Services, Discovery Mode, or a Validated Solution is the right starting point.
Ready to discuss your project? Share a few details and one of our specialists will be in touch.
Discovery Services FAQ
Common questions about project scope, customization, downstream data, timelines, workflow transfer, confidentiality, and post-project support.
Common questions about project scope, customization, downstream data, timelines, workflow transfer, confidentiality, and post-project support.
What is the difference between Discovery Mode, Validated Solutions, and Discovery Services?
Discovery Mode supports flexible development of new or customized 3D models. Validated Solutions provide predefined workflows for specific contexts of use. Discovery Services provides Inventia scientific support to develop, run, optimize, or transfer 3D disease model workflows when additional customization or study execution is needed.
What are Inventia Discovery Services?
Inventia Discovery Services help researchers develop, optimize, run, and transfer RASTRUM-based 3D disease model workflows. Services can support teams that need a disease model, therapeutic-response study, feasibility assessment, assay readout, reporting package, or custom context-of-use workflow for a specific program.
How does Inventia help optimize 3D cell models?
Researchers can use RASTRUM workflows to optimize many 3D model parameters, including matrix selection, cell density, cell ratios, architecture, culture conditions, timing, morphology, viability, QC criteria, and downstream assay compatibility. Discovery Services can be added when teams need Inventia scientists to accelerate model design, assess feasibility, refine conditions, generate supporting data, or prepare a workflow for transfer.
Can Inventia run 3D screening programs for customers?
Yes. Through Discovery Services, Inventia can run treatment-response, screening, or functional studies using RASTRUM-based 3D disease models when the project scope, cells, matrix, architecture, assay, and readouts are technically feasible. Project design, deliverables, and transfer options are defined during scoping.
What is a custom RASTRUM disease model workflow?
A custom RASTRUM disease model workflow is a 3D workflow developed or adapted for a customer’s specific disease biology, cell source, co-culture, assay, readout, or context of use when an existing Validated Solution does not fully meet the need. Deliverables depend on agreed project scope, supporting data, and success criteria.
How does workflow transfer work in a Discovery Services project?
Workflow transfer can include protocols, data packages, images, model and assay recommendations, QC guidance, training, troubleshooting, and scientific support. The goal is to help customers reproduce or continue a disease model workflow in their own lab when appropriate. The transfer plan depends on project scope and customer readiness.
Can a RASTRUM workflow move from Inventia-led services into a customer’s lab?
Yes. Discovery Services can support a path where Inventia helps develop, optimize, or run an initial 3D disease model workflow and then transfers protocols, data, recommendations, and practical know-how to the customer’s team for in-house implementation. The transfer plan depends on project scope and customer readiness.
Can a RASTRUM Validated Solution be customized?
An available RASTRUM Validated Solution can sometimes serve as a starting framework when a customer needs different cells, assays, readouts, matrices, or biological constraints than the predefined workflow supports. Changes may require additional optimization and supporting evidence. Depending on scope, customization may be handled through Discovery Mode or Discovery Services.
What downstream applications can Discovery Services support?
Discovery Services can support or adapt downstream workflows when they are feasible for the disease model and study question, including high-content imaging, viability assays, gene expression, metabolic analysis, cytokine analysis, omics workflows, phenotypic screening, functional endpoint development, and novel readouts.
What does a customer receive at the end of a Discovery Services project?
Depending on project scope, customers may receive study design, recommended 3D model conditions, matrix and architecture guidance, assay and readout recommendations, treatment-response or functional data, scientific interpretation, protocols or SOP-style guidance, QC criteria, and workflow transfer support. Deliverables should be defined in the statement of work before the project begins.
How does a Discovery Services project start?
A Discovery Services project typically starts with a discussion of the customer’s disease biology, therapeutic question, model requirements, cell system, materials, context of use, readouts, timeline, and success criteria. Inventia then scopes the work, prepares a tailored statement of work, and begins kickoff and materials transfer after approval.
How long does a Discovery Services project take to start?
Discovery Services project start times vary depending on customization, complexity, material availability, and project scope. Many projects can begin within 2-4 weeks after approval, but timelines should be confirmed during scoping.
Who owns the data from a Discovery Services project?
Data ownership and confidentiality are governed by the applicable agreement. Customers own the project-specific data generated through their Discovery Services project, subject to the terms of the applicable agreement. Inventia retains ownership of its underlying RASTRUM technology and any associated improvements, including Matrix products, model architectures, platform methods, and know-how.
What support is available after a Discovery Services project is complete?
Post-project support may include scientific consultation, troubleshooting, workflow adaptation, technology-transfer support, remote technical support, and Customer Success support for RASTRUM users. The exact support model depends on the project scope, technology-transfer plan, and whether the workflow is being adopted in-house.
How do I know whether to use a Validated Solution or Discovery Services?
Use a Validated Solution when a predefined workflow already matches your biological context of use. Use Discovery Services when you need a different disease model, cell source, co-culture, matrix condition, readout, or therapeutic question developed or adapted with Inventia scientific support.
What disease models can Inventia Discovery Services support?
Inventia Discovery Services can support RASTRUM-based 3D disease model development across oncology and tumor microenvironment research, including pancreatic cancer / PDAC, colorectal cancer, ovarian, breast, and lung cancer contexts; immuno-oncology; fibrosis and stromal biology; neurodegenerative disease; and custom disease models where the cells, matrix, architecture, culture conditions, and readouts are technically feasible.
Can Inventia develop a custom 3D disease model for my therapeutic program?
Discovery Services can help assess, develop, run, and transfer custom 3D disease model workflows when an existing Validated Solution does not fully fit. Projects typically begin by defining the disease biology, cell system, therapeutic question, context of use, readouts, timeline, and success criteria.
What cell inputs can Inventia Discovery Services work with?
RASTRUM technology is compatible with a broad range of cell inputs. Rather than maintaining a proprietary cell bank, our Discovery Services team sources suitable commercially available cells or works with client-provided proprietary material. Via partnerships with multiple commercial cell providers, we can access established cell lines, primary cells and patient-derived tumoroids. Contact our team to identify the most appropriate cell inputs for your disease model and research program.
Can Discovery Services support oncology and tumor microenvironment models?
Discovery Services can support oncology and tumor microenvironment model development, including tumor-stroma co-culture, CAF biology, dense tumor biology, treatment response, and custom context-of-use studies. Disease areas may include PDAC, colorectal cancer, ovarian, breast, and lung cancer, depending on project feasibility.
Can Discovery Services support immuno-oncology models?
Discovery Services can support immuno-oncology model development where tumor-immune interactions, immune-cell behavior, infiltration, cytokine response, or immune-mediated activity are central to the research question. Suitability depends on cell sources, matrix, architecture, timing, and readouts.
Can Discovery Services support fibrosis or stromal biology models?
Discovery Services can support fibrosis and stromal biology workflows involving fibroblast activation, CAF biology, stromal signaling, extracellular matrix remodeling, and treatment-response questions where the model can be designed around compatible cells, matrices, architectures, and readouts.
Can Discovery Services support neurodegenerative disease models?
Discovery Services can support custom 3D model development for neurodegenerative disease research where a fit-for-purpose model is needed to represent disease biology, evaluate treatment response, or generate feasibility data. Model scope depends on cell type, culture conditions, matrix, architecture, and readouts.