PDAC-IO Validated Solution Data Sheet
Overview
Study tumor-stroma-immune interactions and checkpoint inhibitor responses by adding CD8+ T cells to a defined 3D pancreatic ductal adenocarcinoma (PDAC) tumor-stroma model.
The PDAC-IO Validated Solution adds pre-activated human CD8+ T cells to the PDAC Validated Solution, which combines PANC-1 pancreatic cancer cells with primary cancer-associated fibroblasts (CAFs) in a defined 3D matrix bioprinted with RASTRUM Allegro. This Data Sheet summarizes the model, its imaging and RNA-seq data, and its responses to reference treatments.
Context of use
- Evaluate immunotherapy efficacy in the presence of tumor-stroma-immune crosstalk
- Investigate how cancer-associated fibroblasts (CAFs) shape tumor signaling and CD8+ T cell function
- Identify targetable mechanisms of stroma-mediated immune suppression within the tumor microenvironment
- Screen immune checkpoint inhibitors and stroma-targeted combination treatments