PDAC Validated Solution Data Sheet
Overview
Accelerate the development of effective therapies for pancreatic ductal adenocarcinoma (PDAC) using a reproducible 3D tumor–stroma model designed for translational research workflows.
The PDAC Validated Solution recreates tumor–stroma interactions by integrating pancreatic cancer cells with cancer-associated fibroblasts, CAFs, within a defined 3D matrix environment. To incorporate broad coverage of key PDAC signalling pathways and provide canonical TGF-β-driven or TGF-β-null contexts, the workflow combines either PANC-1 or AsPC-1 cancer cells with primary PDAC CAFs. This approach also supports drug efficacy comparisons between primary and metastatic contexts.
Context of use
- Evaluate therapeutic efficacy in the presence of tumor–stroma crosstalk
- Investigate stromal contributions to tumor progression and drug resistance
- Identify targetable resistance mechanisms within the tumor microenvironment
- Screen pathway-targeted therapies and combination treatments