Accelerate the development of effective therapies for pancreatic ductal adenocarcinoma (PDAC) using a reproducible 3D tumor–stroma model designed for translational research workflows.
The PDAC Validated Solution recreates tumor–stroma interactions by integrating pancreatic cancer cells with cancer-associated fibroblasts, CAFs, within a defined 3D matrix environment. To incorporate broad coverage of key PDAC signalling pathways and provide canonical TGF-β-driven or TGF-β-null contexts, the workflow combines either PANC-1 or AsPC-1 cancer cells with primary PDAC CAFs. This approach also supports drug efficacy comparisons between primary and metastatic contexts.
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