Watch the on-demand presentation from Emma Jones, Ph.D., Lead Scientist in Neurobiology at Medicines Discovery Catapult, exploring how human iPSC-derived CNS models are being used to study neuroinflammation across 2D and 3D systems.

Neuroinflammatory responses are shaped by complex cellular interactions that can be difficult to capture using conventional in vitro models alone.

In this session, Emma Jones, Ph.D. presents a workflow for characterizing human iPSC-derived microglia in 2D before transitioning these models into bioprinted 3D CNS environments generated using the RASTRUM™ platform.

The webinar explores how multicellular 3D systems can be used to investigate neuroinflammatory responses using imaging, mitochondrial activity assays, cytokine analysis, and tri-culture approaches.

The session also includes a short presentation from Inventia Life Science demonstrating how scalable bioprinting workflows using the RASTRUM platform support the generation of reproducible 3D CNS models for drug discovery applications.

What you'll learn:

• How human iPSC-derived microglia are characterized using functional assays, imaging, and single-cell analysis
• What changes when transitioning from 2D to 3D CNS model systems
• How microglia integrate into multicellular 3D environments
• Applications of mitochondrial activity and cytokine release assays in neuroinflammation studies
• How scalable 3D workflows support advanced CNS model development for drug discovery
  
  

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